Depression, cortisol and new opportunities for treatments
- (4/4/2007)
Depression is usually characterized by an over activity of the hypothalamic-pituitary-adrenal (HPA) axis that resembles the neuro-endocrine response to stress. I hope to convince you that HPA axis hyperactivity is a crucial biological mechanism in the ...
Carmine M. Pariante MD, MRCPsych, PhD
How to combine antidepressant treatments?
- (1/1/2006)
If an initial antidepressant treatment fails to achieve an adequate improvement and dose increase is not successful, the next step is to add a second agent or switch to another agent. The clear advantages of combination/augmentation include maintenance of ...
Prof. Pierre Blier
How to adapt antidepressant treatment?
- (12/1/2005)
One strategy to improve patient outcome would be to adapt ineffective treatment earlier. However a prerequisite to this approach is knowing when and how to adapt treatment. In the previous two lectures, Prof. Armin Szegedi addressed ‘when’, presenting ...
Prof. Pierre Blier
When to adapt antidepressant treatment?
- (11/7/2005)
In order to know when to adapt treatment, it must be possible to predict treatment outcome at a certain moment during the treatment course. Obviously the earlier outcome can be reliably predicted the better. In the first part of this presentation, partial ...
Professor Dr. Armin Szegedi
How to predict outcome of antidepressant treatment?
- (11/5/2005)
Full remission - the ultimate goal of treatment – is not achieved by all patients following an acute trial of antidepressant treatment. As reliable predictors of response and remission prior to initiating pharmacotherapy have not yet been established, a ...
Professor Dr. Armin Szegedi